Copper(ii)l/d-valine-(1,10-phen) complexes target human telomeric G-quadruplex motifs and promote site-specific DNA cleavage and cellular cytotoxicity-Reference-Cited by-同舟云学术

Copper(ii)l/d-valine-(1,10-phen) complexes target human telomeric G-quadruplex motifs and promote site-specific DNA cleavage and cellular cytotoxicity

Published:2020 Issue:28 Volume:49 Page:9888-9899
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Arjmand Farukh¹²³⁴^ORCID,Sharma Surbhi¹²³⁴,Parveen Sabiha¹²³⁴,Toupet Loic⁵⁶⁷⁸⁹,Yu Zhen¹⁰¹¹¹²¹³^ORCID,Cowan J. A.¹⁰¹¹¹²¹³

Affiliation:

1. Department of Chemistry

2. Aligarh Muslim University

3. Aligarh 202002

4. India

5. Institut de Physique de sRennes

6. UMR 625

7. Université de Rennes 1

8. 35042 Rennes Cedex

9. France

10. Department of Chemistry and Biochemistry

11. The Ohio State University

12. Columbus

13. USA

Abstract

Chirall-/d-valine-(1,10-phen)-Cu(ii) complexes that target G-quadruplex DNA were synthesized and thoroughly characterized. The cytotoxic activity of1aand1bon some of the notably important cancer cell lines was evaluated by MTT assay.

Funder

Department of Science and Technology, Ministry of Science and Technology

University Grants Commission

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/DT/D0DT01527J

Reference81 articles.

1. A dinuclear ruthenium(ii) phototherapeutic that targets duplex and quadruplex DNA