Ruthenium–arene complexes bearing naphthyl-substituted 1,3-dioxoindan-2-carboxamides ligands for G-quadruplex DNA recognition

Author:

Hager Laura A.1234,Mokesch Stephan1234,Kieler Claudia56734,Alonso-de Castro Silvia8910,Baier Dina56734,Roller Alexander1234,Kandioller Wolfgang1234ORCID,Keppler Bernhard K.1234,Berger Walter56734ORCID,Salassa Luca89101112ORCID,Terenzi Alessio12348ORCID

Affiliation:

1. Institute of Inorganic Chemistry

2. Faculty of Chemistry, University of Vienna

3. A-1090 Vienna

4. Austria

5. Department of Medicine I

6. Institute of Cancer Research and Comprehensive Cancer Center

7. Medical University Vienna

8. Donostia International Physics Center

9. Donostia

10. Spain

11. Ikerbasque

12. Basque Foundation for Science

Abstract

Ru(ii) arene complexes with 1,3-dioxoindan-2-carboxamides ligands bearing pendant naphthyl-groups designed to bind G-quadruplex DNA structures by both stacking and coordinating interactions.

Funder

Seventh Framework Programme

Horizon 2020

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Reference50 articles.

1. Quadruplex nucleic acids as targets for anticancer therapeutics

2. DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential

3. R. Vilar , in Metallo-Drugs: Development and Action of Anticancer Agents , ed. A. Sigel , H. Sigel , E. Freisinger and R. K. O. Sigel , De Gruyter , Berlin, Boston , 2018 , pp. 325–350

4. G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs

5. Interaction of Metal Complexes with G-Quadruplex DNA

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