Chemoselective efficient synthesis of functionalized β-oxonitriles through cyanomethylation of Weinreb amides
Author:
Affiliation:
1. Department of Pharmaceutical Chemistry
2. University of Vienna
3. Vienna
4. Austria
5. Department of Chemistry and Pharmacy
6. University of Sassari
7. Sassari
8. Italy
Abstract
Homologation of Weinreb amides with cyanomethyllithium: a new route to β-oxonitriles.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB02398F
Reference72 articles.
1. The Chemistry of 3-Oxoalkanenitriles
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3. Cyclic Oxonitriles: Synergistic Juxtaposition of Ketone and Nitrile Functionalities
4. De Novo Parallel Design, Synthesis and Evaluation of Inhibitors against the Reverse Transcriptase of Human Immunodeficiency Virus Type-1 and Drug-Resistant Variants
5. Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore
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