Synthesis of 3-substituted 2-oxindoles from secondary α-bromo-propionanilides <i>via</i> palladium-catalyzed intramolecular cyclization-Reference-Cited by-同舟云学术

Synthesis of 3-substituted 2-oxindoles from secondary α-bromo-propionanilides via palladium-catalyzed intramolecular cyclization

Published:2022 Issue:17 Volume:20 Page:3589-3597
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Shen Hui¹²,Du Yu¹²^ORCID,Kan Jian¹²,Su Weiping¹²³^ORCID

Affiliation:

1. College of Chemistry & Materials Science, Fujian Normal University, Fuzhou 350007, P. R. China

2. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 Yangqiao Road West, Fuzhou 350002, P. R. China

3. Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fuzhou 350108, P. R. China

Abstract

A Pd-catalyzed cyclization of α-bromo-propionanilides for the synthesis of 3-substituted 2-oxindoles has been developed. This method features easy to prepare starting materials, broad substrate scope and good functional group tolerance.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Key Research Program of Frontier Science, Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00480A

Reference108 articles.

1. Oxindole and its derivatives: A review on recent progress in biological activities