Acenaphthoimidazolylidene‐ligated chiral oxazoline palladacycles: synthesis, structure, and application in intramolecular α‐arylation of amides towards 3,3′‐disubstituted oxindoles

Abstract

AbstractA general catalytic protocol for the Pd‐catalyzed intramolecular arylations of N‐(2‐halogenoaryl) amides in eco‐friendly medium was successfully developed by using rationally designed acenaphthoimidazolylidene‐ligated chiral oxazoline palladacycles. Under the optimal reaction condition, a broad scope of substrates with various functional groups were well tolerated, leading to desired 3,3′‐disubstituted oxindoles in excellent yields (up to 98% yield).