Novel spirocyclic systems via multicomponent aza-Diels–Alder reaction-Reference-Cited by-同舟云学术

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Novel spirocyclic systems via multicomponent aza-Diels–Alder reaction

Published:2017 Issue:37 Volume:15 Page:7758-7764
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Llona-Minguez Sabin¹²³⁴⁵^ORCID,Throup Adam¹²³⁴⁵^ORCID,Steiner Emilie⁶²³⁴⁵,Lightowler Molly¹²³⁴⁵,Van der Haegen Sandra¹²³⁴⁵,Homan Evert¹²³⁴⁵^ORCID,Eriksson Lars⁷⁸⁴⁵,Stenmark Pål⁹⁸⁴⁵,Jenmalm-Jensen Annika¹⁰¹²³⁴,Helleday Thomas¹²³⁴⁵

Affiliation:

1. Division of Translational Medicine and Chemical Biology

2. Department of Medical Biochemistry and Biophysics

3. Karolinska Institute

4. Stockholm

5. Sweden

6. Division of Molecular Structural Biology

7. Department of Materials and Environmental Chemistry

8. Stockholm University

9. Department of Biochemistry and Biophysics

10. Chemical Biology Consortium Sweden

Abstract

Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels–Alder reaction.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB02069D

Reference40 articles.

1. The re-emergence of natural products for drug discovery in the genomics era

2. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

3. Improvement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and Symmetry

4. The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

5. Natural products: A continuing source of novel drug leads

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1. Recent Applications of the Diels–Alder Reaction in the Synthesis of Natural Products (2017–2020);Synthesis;2021-06-21

2. Features of 3-amino-5-methylisoxazole in heterocyclizations involving pyruvic acids;Chemistry of Heterocyclic Compounds;2019-01

3. Recent advances of the Povarov reaction in medicinal chemistry;Drug Discovery Today: Technologies;2018-11

4. Intramolecular Imino-ene Reaction of 2H-azirines with Alkenes: Rapid Construction of Spiro NH Aziridines from Vinyl Azides;Organic Letters;2018-05-16

5. l-Proline-Catalysed One-Pot aza-Diels–Alder Reaction in Water: Regioselective Synthesis of Spiro(isoxazolo[5,4-b]pyridine-5,5′-pyrimidine) Derivatives;Synlett;2018-03-20

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