Improvement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and Symmetry
Author:
Affiliation:
1. Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm101356p
Reference79 articles.
1. When poor solubility becomes an issue: From early stage to proof of concept
2. Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate
3. Solubility: it's not just for physical chemists
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