Live cell off-target identification of lapatinib using ligand-directed tosyl chemistry-Reference-Cited by-同舟云学术

Live cell off-target identification of lapatinib using ligand-directed tosyl chemistry

Published:2014 Issue:91 Volume:50 Page:14097-14100
ISSN:1359-7345
Container-title:Chem. Commun.
language:en
Short-container-title:Chem. Commun.

Author:

Yamaura Kei¹²³⁴,Kuwata Keiko⁵⁶⁷,Tamura Tomonori¹²³⁴,Kioi Yoshiyuki¹²³⁴,Takaoka Yousuke¹²³⁴,Kiyonaka Shigeki¹²³⁴,Hamachi Itaru¹²³⁴⁸

Affiliation:

1. Graduate School of Engineering

2. Department of Synthetic Chemistry and Biological Chemistry

3. Kyoto University

4. Kyoto 615-8510, Japan

5. Institute of Transformative Bio-Molecules (ITbM)

6. Nagoya University

7. Nagoya 464-8602, Japan

8. Core Research for Evolutional Science and Technology (CREST)

Abstract

We demonstrate that ligand-directed tosyl (LDT) chemistry is applicable to off-target identification in live cells.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2014/CC/C4CC05885B

Reference41 articles.

1. Predicting new molecular targets for known drugs

2. On the origins of drug polypharmacology

3. Off-Target Decoding of a Multitarget Kinase Inhibitor by Chemical Proteomics

4. Capture Compound Mass Spectrometry Sheds Light on the Molecular Mechanisms of Liver Toxicity of Two Parkinson Drugs

5. Biochemical Target Isolation for Novices: Affinity-Based Strategies

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Multisite Labeling of Proteins Using the Ligand-Directed Reactivity of Triggerable Michael Acceptors;Bioconjugate Chemistry;2023-05-23

2. Different chemical proteomic approaches to identify the targets of lapatinib;Journal of Enzyme Inhibition and Medicinal Chemistry;2023-03

3. Precision Targeting of Endogenous Epidermal Growth Factor Receptor (EGFR) by Structurally Aligned Dual-Modifier Labeling;ACS Pharmacology & Translational Science;2022-09-19

4. Harnessing affinity-based protein profiling to reveal a novel target of nintedanib;Chemical Communications;2021

5. Molecular Technologies in Life Innovation: Novel Molecular Technologies for Labeling and Functional Control of Proteins Under Live Cell Conditions;Molecular Technology;2019-02-27