Harnessing affinity-based protein profiling to reveal a novel target of nintedanib-Reference-Cited by-同舟云学术

Harnessing affinity-based protein profiling to reveal a novel target of nintedanib

Published:2021 Issue:25 Volume:57 Page:3139-3142
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Chen Xiong¹²³⁴⁵,Li Menglin¹²³⁴⁵,Li Manru¹²³⁴⁵,Wang Dongmei¹²³⁴⁵^ORCID,Zhang Jinlan¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines

2. Institute of Materia Medica

3. Chinese Academy of Medical Sciences and Peking Union Medical College

4. Beijing 100050

5. China

Abstract

We identified tripeptidyl-peptidase 1 (TPP1) as one of the direct targets of nintedanib (NDNB) employing clickable photoaffinity probes, which provides insights into the functional meaning of the well-known IPF therapeutic drug.

Funder

Chinese Academy of Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D1CC00354B

Reference24 articles.

1. Targeting FGFR/PDGFR/VEGFR Impairs Tumor Growth, Angiogenesis, and Metastasis by Effects on Tumor Cells, Endothelial Cells, and Pericytes in Pancreatic Cancer

2. Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial

3. Pazopanib for the Treatment of Metastatic Renal Cell Carcinoma

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