Nintedanib exerts anti-pulmonary fibrosis activity <i>via</i> inhibiting TANK-binding kinase 1 (TBK1) phosphorylation-Reference-Cited by-同舟云学术

Nintedanib exerts anti-pulmonary fibrosis activity via inhibiting TANK-binding kinase 1 (TBK1) phosphorylation

Published:2022 Issue:8 Volume:58 Page:1199-1202
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Li Manru¹,Zhou Yu¹,Wang Tiantian¹,Li Menglin¹,Chen Xiong¹,Zhang Tiantai¹,Wang Dongmei¹^ORCID,Zhang Jinlan¹^ORCID

Affiliation:

1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Abstract

We described a chemoproteomics approach to identify TBK1 as a key target of the multikinase inhibitor nintedanib in IPF. This insight may facilitate a better understanding of the functional mechanism of nintedanib for antifibrosis efficacy.

Funder

Chinese Academy of Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D1CC05621B

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