On the origins of drug polypharmacology
Author:
Affiliation:
1. Chemogenomics Laboratory
2. Research Programme on Biomedical Informatics (GRIB)
3. IMIM Hospital del Mar Research Institute and University Pompeu Fabra
4. Parc de Recerca Biomèdica
5. 08003 Barcelona
Abstract
The ability of many drugs, unintended most often, to interact with multiple proteins is commonly referred to as polypharmacology. Could this be a reminiscent chemical signature of early protein evolution?
Publisher
Royal Society of Chemistry (RSC)
Subject
Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2013/MD/C2MD20242E
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