The material-enabled oxygen control in thiol-ene microfluidic channels and its feasibility for subcellular drug metabolism assays under hypoxia in vitro-Reference-Cited by-同舟云学术

The material-enabled oxygen control in thiol-ene microfluidic channels and its feasibility for subcellular drug metabolism assays under hypoxia in vitro

Published:2021 Issue:9 Volume:21 Page:1820-1831
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Kiiski Iiro¹²³⁴⁵^ORCID,Järvinen Päivi¹²³⁴⁵^ORCID,Ollikainen Elisa¹²³⁴⁵,Jokinen Ville⁶⁷⁸⁹¹⁰^ORCID,Sikanen Tiina¹²³⁴⁵^ORCID

Affiliation:

1. Faculty of Pharmacy

2. Drug Research Program

3. Division of Pharmaceutical Chemistry and Technology

4. University of Helsinki

5. Helsinki

6. Department of Materials Science and Engineering

7. School of Chemical Engineering

8. Aalto University

9. Espoo

10. Finland

Abstract

This work demonstrates the feasibility of material-enabled oxygen scavenging in thiol-ene microchannels for on-chip subcellular drug metabolism assays under hypoxia.

Funder

Academy of Finland

Helsingin Yliopisto

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/LC/D0LC01292K

Reference44 articles.

1. Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

2. Oxygen Sensing, Homeostasis, and Disease