Strain-enabled radical spirocyclization cascades: rapid access to spirocyclobutyl lactones and

Strain-enabled radical spirocyclization cascades: rapid access to spirocyclobutyl lactones and – lactams

Published:2024 Issue: Volume: Page:
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Das Kousik¹,Pedada Abhilash¹,Singha Tushar¹^ORCID,Hari Durga Prasad¹^ORCID

Affiliation:

1. Department of Organic Chemistry, Indian Institute of Science, Bangalore, India, 560012

Abstract

Two complementary strain-enabled radical spirocyclization cascades have been realized to synthesize spirocyclobutyl lactones and – lactams. The reactions operate under mild conditions and demonstrate excellent functional group compatibility.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC05700C

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