Synthetic Routes to Approved Drugs Containing a Spirocycle

Author:

Moshnenko Nazar1,Kazantsev Alexander1ORCID,Chupakhin Evgeny2ORCID,Bakulina Olga1,Dar’in Dmitry13ORCID

Affiliation:

1. Institute of Chemistry, Saint Petersburg State University, 199034 Saint Petersburg, Russia

2. Institute of Living Systems, Immanuel Kant Baltic Federal University, 236016 Kaliningrad, Russia

3. Saint Petersburg Research Institute of Phthisiopulmonology, 191036 Saint Petersburg, Russia

Abstract

The use of spirocycles in drug discovery and medicinal chemistry has been booming in the last two decades. This has clearly translated into the landscape of approved drugs. Among two dozen clinically used medicines containing a spirocycle, 50% have been approved in the 21st century. The present review focuses on the notable synthetic routes to such drugs invented in industry and academia, and is intended to serve as a useful reference source of synthetic as well as general drug information for researchers engaging in the design of new spirocyclic scaffolds for medicinal use or embarking upon analog syntheses inspired by the existing approved drugs.

Funder

Russian Foundation for Basic Research

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

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