Exploring the Reactivity of Rigid 1-Azadienes Derived from Methylene γ-Lactams. Applications to the Stereoselective Synthesis of Spiro-γ-Lactams-Reference-Cited by-同舟云学术

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Exploring the Reactivity of Rigid 1-Azadienes Derived from Methylene γ-Lactams. Applications to the Stereoselective Synthesis of Spiro-γ-Lactams

Published:2024-06-19 Issue:13 Volume:89 Page:9502-9515
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

López-Francés Adrián¹^ORCID,Serna-Burgos Zuriñe¹,del Corte Xabier¹,de los Santos Jesús M.¹^ORCID,de Cózar Abel²³^ORCID,Vicario Javier¹^ORCID

Affiliation:

1. Department of Organic Chemistry I, Faculty of Pharmacy, University of the Basque Country, UPV/EHU. Paseo de la Universidad 7, Vitoria-Gasteiz 01006, Spain

2. Department of Organic Chemistry I, Donostia International Physics Centre (DIPC), University of the Basque Country, UPV/EHU. Paseo Manuel de Lardizabal, 3, Donostia-San Sebastián 20018, Spain

3. Ikerbasque, Basque Foundation for Science, Plaza Euskadi 5, Bilbao 48009, Spain

Funder

Ministerio de Ciencia, InnovaciÃ³n y Universidades

Eusko Jaurlaritza

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.4c00822

Reference49 articles.

1. Spiro Compounds

2. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

3. Charting Biologically Relevant Spirocyclic Compound Space

4. Spirocyclic Scaffolds in Medicinal Chemistry

5. The use of spirocyclic scaffolds in drug discovery

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