Reprogramming the sulfur recycling network to improve l-cysteine production in Corynebacterium glutamicum

Author:

Du Huanmin123,Qiao Jinfang4,Qi Yuting5,Li Lingcong123,Xu Ning12,Shao Li5,Wei Liang12ORCID,Liu Jun12

Affiliation:

1. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China

2. Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China

3. University of Chinese Academy of Sciences, Beijing 100049, China

4. College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China

5. Department of Microbiology and Biotechnology, College of Life Sciences, Northeast Agricultural University, No. 600 Changjiang Road, Xiangfang District, Harbin 150030, China

Abstract

A bifunctional H2S2-responsive genetic circuit was established to realize sulfur recycling in Corynebacterium glutamicum, and the production of l-cysteine and the SCR were significantly increased by using this system.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

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