High-yielding18F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptakein vivo-Reference-Cited by-同舟云学术

High-yielding18F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptakein vivo

Published:2018 Issue:58 Volume:54 Page:8120-8123
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Beard Rhiannon¹²³⁴⁵^ORCID,Singh Nisha⁶⁷⁴⁵⁸,Grundschober Christophe⁹¹⁰¹¹¹²¹³^ORCID,Gee Antony D.⁶⁷⁴⁵^ORCID,Tate Edward W.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Imperial College London

3. Exhibition Road

4. London

5. UK

6. Division of Imaging Sciences

7. King's College London

8. Centre for Neuroimaging Sciences

9. Roche Pharma Research and Early Development

10. Discovery Neuroscience

11. Roche Innovation Center Basel

12. F. Hoffmann-La Roche Ltd

13. 4070 Basel

Abstract

Probing the mechanism of intranasal oxytocin brain uptake through generation and validation of a novel peptide PET tracer.

Funder

Medical Research Council

Engineering and Physical Sciences Research Council

Wellcome Trust

Seventh Framework Programme

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC01400K

Reference32 articles.

1. The Oxytocin Receptor System: Structure, Function, and Regulation

2. Intranasal oxytocin reduces psychotic symptoms and improves Theory of Mind and social perception in schizophrenia

3. Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism

4. Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders

5. The promise and pitfalls of intranasally administering psychopharmacological agents for the treatment of psychiatric disorders

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