Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism-Reference-Cited by-同舟云学术

Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism

Published:2015-01-21 Issue:271 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Peñagarikano Olga¹²,Lázaro María T.¹,Lu Xiao-Hong³,Gordon Aaron⁴,Dong Hongmei¹,Lam Hoa A.⁵,Peles Elior⁴,Maidment Nigel T.⁵,Murphy Niall P.⁵,Yang X. William³,Golshani Peyman¹⁶⁷,Geschwind Daniel H.¹²³

Affiliation:

1. Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

2. Center for Autism Research and Treatment and Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90095, USA.

3. Center for Neurobehavioral Genetics, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA.

4. Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.

5. Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90095, USA.

6. Integrative Center for Learning and Memory, University of California, Los Angeles, Los Angeles, CA 90095, USA.

7. West Los Angeles VA Medical Center, Los Angeles, CA 90073, USA.

Abstract

Mice carrying a genetic mutation that causes autistic symptoms show improved sociability after being treated with oxytocin, a hormone promoting mothering and trust.

Funder

NIH

National Institute of Mental Health (NIMH)

NIH/National Institute of Neurological Disorders and Stroke (NINDS)

Autism Speaks

Simons Foundation Autism Research Initiative

McKnight Foundation

NIH Autism Centers of Excellence (ACE)

Network

UCLA Center for Autism Research and Treatment (CART) Pilot

Publisher

American Association for the Advancement of Science (AAAS)