Synthesis of 1- and 4-substituted piperazin-2-ones via Jocic-type reactions with N-substituted diamines-Reference-Cited by-同舟云学术

Synthesis of 1- and 4-substituted piperazin-2-ones via Jocic-type reactions with N-substituted diamines

Published:2015 Issue:8 Volume:13 Page:2360-2365
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Perryman Michael S.¹²³⁴,Earl Matthew W. M.¹²³⁴,Greatorex Sam¹²³⁴,Clarkson Guy J.¹²³⁴,Fox David J.¹²³⁴

Affiliation:

1. Department of Chemistry

2. University of Warwick

3. Coventry

4. U.K

Abstract

Enantiomerically-enriched trichloromethyl-containing alcohols are transformed regioselectively into enantiomerically-enriched 1-substituted piperazinones by modified Jocic reactions.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB02311K

Reference88 articles.

1. SYNTHESES AND TRANSFORMATIONS OF PIPERAZINONE RINGS. A REVIEW

2. The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures

3. Mastering chiral substituted 2-oxopiperazines

4. Dynamic resolution of α-halo chiral esters for the synthesis of 3-substituted piperazin-2-ones

5. Synthesis and Pharmacological Evaluation of Novel Arylpiperazine Derivatives as Nonsteroidal Androgen Receptor Antagonists

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A facile route for highly enantioenriched six‐membered 1,4‐N,N‐ and N,O‐heterocycles from L‐serinate‐derived α‐bromoacetates;Bulletin of the Korean Chemical Society;2023-10-14

2. Asymmetric Catalytic Access to Piperazin-2-ones and Morpholin-2-ones in a One-Pot Approach: Rapid Synthesis of an Intermediate to Aprepitant;The Journal of Organic Chemistry;2023-02-21

3. Peptidomimetic Small-Molecule Inhibitors of 3CLPro Activity and Spike–ACE2 Interaction: Toward Dual-Action Molecules against Coronavirus Infections;The Journal of Organic Chemistry;2022-08-30

4. Pd-catalyzed synthesis of 1-(hetero)aryl-2,2,2-trichloroethanols using chloral hydrate and (hetero)arylboroxines;RSC Advances;2021

5. Synthesis of chiral piperazin-2-ones through palladium-catalyzed asymmetric hydrogenation of pyrazin-2-ols;Organic Chemistry Frontiers;2021