Synthesis of chiral piperazin-2-ones through palladium-catalyzed asymmetric hydrogenation of pyrazin-2-ols-Reference-Cited by-同舟云学术

Synthesis of chiral piperazin-2-ones through palladium-catalyzed asymmetric hydrogenation of pyrazin-2-ols

Published:2021 Issue:22 Volume:8 Page:6273-6278
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Feng Guang-Shou¹^ORCID,Zhao Zi-Biao¹^ORCID,Shi Lei²^ORCID,Zhou Yong-Gui¹³^ORCID

Affiliation:

1. State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China

2. School of Chemical Engineering, Dalian University of Technology, Dalian 116024, P. R. China

3. Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian 116024, P. R. China

Abstract

A palladium-catalyzed asymmetric hydrogenation of pyrazines containing a tautomeric hydroxyl group was developed, providing a facile access to chiral disubstituted piperazin-2-ones with excellent diastereoselectivities and enantioselectivities.

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/QO/D1QO01144H

Reference41 articles.

1. Mastering chiral substituted 2-oxopiperazines

2. Peptidomimetics for Receptor Ligands?Discovery, Development, and Medical Perspectives

3. SYNTHESES AND TRANSFORMATIONS OF PIPERAZINONE RINGS. A REVIEW

4. Praziquantel and the Control of Schistosomiasis

5. Enantioselective synthesis of (R)-(−)-praziquantel (PZQ)

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