Highly Enantioselective Ir-Catalyzed Hydrogenation of Pyrazolo[1,5-<i>a</i>]pyrimidine for the Synthesis of Zanubrutinib-Reference-Cited by-同舟云学术

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Highly Enantioselective Ir-Catalyzed Hydrogenation of Pyrazolo[1,5-a]pyrimidine for the Synthesis of Zanubrutinib

Published:2024-01-23 Issue:3 Volume:89 Page:1748-1752
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Yuan Haohuan¹,Yao Wei¹,Zhang Xiaomin¹,Wei Zhao¹,Xi Jiayue¹,Hao Yuanyuan²,Liu Xian³,Jiang Ru¹^ORCID,Nie Huifang¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China

2. Xi’an Central Hospital, Xi’an 710003, China

3. Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China

Funder

National Natural Science Foundation of China

Foundation of Fourth Military Medical University

Xi'an Postdoctoral Innovation Base Project

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.3c02446

Reference26 articles.

1. Simultaneous development of zanubrutinib in the USA and China

2. Zanubrutinib succeeds in head-to-head with ibrutinib in R/R CLL

3. Zanubrutinib or Ibrutinib in Relapsed or Refractory Chronic Lymphocytic Leukemia

4. Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies

5. Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers

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