Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods-Reference-Cited by-同舟云学术

Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods

Published:2015 Issue:18 Volume:51 Page:3816-3819
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Ordanini Stefania¹²³⁴,Varga Norbert¹²³⁴,Porkolab Vanessa⁵⁶⁷⁸⁹,Thépaut Michel⁵⁶⁷⁸⁹,Belvisi Laura¹²³⁴¹⁰,Bertaglia Andrea¹²³⁴,Palmioli Alessandro¹²³⁴,Berzi Angela¹¹¹²³⁴,Trabattoni Daria¹¹¹²³⁴,Clerici Mario¹¹¹³¹⁴⁴¹⁵,Fieschi Franck⁵⁶⁷⁸⁹,Bernardi Anna¹²³⁴¹⁰

Affiliation:

1. Università degli Studi di Milano (UniMI)

2. Dip. Chimica

3. Milano

4. Italy

5. Univ. Grenoble Alpes

6. Inst. de Biologie Structurale

7. Grenoble

8. France

9. CNRS

10. CNR-ISTM

11. UniMI

12. Dip. Scienze Biomediche e Cliniche “L. Sacco”

13. Dip. Fisiopatologia Medico-Chirurgica e Trapianti

14. Segrate

15. Fondazione Don Carlo Gnocchi IRCCS

Abstract

Rational design of DC-SIGN antagonists combines a selective glycomimetic ligand with trivalent dendrons spaced by a rigid core and allows to exploit multiple multivalency effects.

Funder

European Commission Directorate-General for Research and Innovation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CC/C4CC09709B

Reference17 articles.

1. Multivalent glycoconjugates as anti-pathogenic agents

2. Maximising multivalency effects in protein–carbohydrate interactions

3. Dependence of Avidity on Linker Length for a Bivalent Ligand–Bivalent Receptor Model System

4. V. M. Krishnamurthy , L. A.Estroff and G. M.Whitesides, in Fragment based approaches in drug discovery, ed. W. Jahnke and D. A. Erlanson, Wiley-VCH, 2006, pp. 11–53

5. Efficient synthesis of phenylene-ethynylene rods and their use as rigid spacers in divalent inhibitors

Cited by 80 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Total Synthesis of Core 3 & Core 4‐Type Mucin Glycan Derivatives;Helvetica Chimica Acta;2024-05-03

2. The Research Status of Novel Coronavirus Antibodies and Small Molecule Inhibitors;PROG BIOCHEM BIOPHYS;2024

3. Unprecedented selectivity for homologous lectin targets: differential targeting of the viral receptors L-SIGN and DC-SIGN;Chemical Science;2024

4. Small lectin ligands as a basis for applications in glycoscience and glycomedicine;Chemical Society Reviews;2024

5. Quantification of thermodynamic effects of carbohydrate multivalency on avidity using synthetic discrete glycooligomers;Chemical Communications;2024