Unprecedented selectivity for homologous lectin targets: differential targeting of the viral receptors L-SIGN and DC-SIGN-Reference-Cited by-同舟云学术

Unprecedented selectivity for homologous lectin targets: differential targeting of the viral receptors L-SIGN and DC-SIGN

Published:2024 Issue: Volume: Page:
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Delaunay Clara¹,Pollastri Sara²^ORCID,Thépaut Michel¹,Cavazzoli Gianluca²,Belvisi Laura²^ORCID,Bouchikri Clémentine¹,Labiod Nuria³,Lasala Fatima³,Gimeno Ana⁴,Franconetti Antonio⁴^ORCID,Jiménez-Barbero Jesús⁴⁵⁶^ORCID,Ardá Ana⁴⁵,Delgado Rafael³⁷,Bernardi Anna²^ORCID,Fieschi Franck¹⁸^ORCID

Affiliation:

1. Université Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, Grenoble, France

2. Università degli Studi di Milano, Dipartimento di Chimica, via Golgi 19, Milano, Italy

3. Instituto de Investigacion Hospital Universitario 12 de Octubre, Universidad Complutense, School of Medicine, Madrid, Spain

4. Chemical Glycobiology Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), 48160 Derio, Bizkaia, Spain

5. Ikerbasque, Basque Foundation for Science, Bilbao, Spain

6. Centro de Investigacion Biomedica En Red de Enfermedades Respiratorias, 28029 Madrid, Spain

7. School of Medicine, Universidad Complutense, Madrid, Spain

8. Institut Universitaire de France (IUF), Paris, France

Abstract

DC-SIGN and L-SIGN are C-type lectin receptors that act as viral coreceptors for SARS-CoV-2. Their distinct tissue localization justifies the search for a selective ligand for L-SIGN, despite their high homology suggesting the task hard to achieve.

Funder

French Infrastructure for Integrated Structural Biology

Agence Nationale de la Recherche

Comunidad de Madrid

Instituto de Salud Carlos III

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC02980A

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