Lacto-N-tetraose synthesis by wild-type and glycosynthase variants of the β-N-hexosaminidase from Bifidobacterium bifidum-Reference-Cited by-同舟云学术

Lacto-N-tetraose synthesis by wild-type and glycosynthase variants of the β-N-hexosaminidase from Bifidobacterium bifidum

Published:2019 Issue:23 Volume:17 Page:5661-5665
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Schmölzer Katharina¹²³^ORCID,Weingarten Melanie⁴⁵⁶,Baldenius Kai⁴⁵⁶,Nidetzky Bernd¹²³⁷⁸^ORCID

Affiliation:

1. Austrian Centre of Industrial Biotechnology (acib)

2. 8010 Graz

3. Austria

4. BASF SE

5. 67056 Ludwigshafen

6. Germany

7. Institute of Biotechnology and Biochemical Engineering

8. Graz University of Technology

Abstract

Enzymatic lacto-N-biose transfer from lacto-N-biose 1,2-oxazoline to lactose by wild-type and glycosynthase variants of Bifidobacterium bifidum β-N-hexosaminidase yielded lacto-N-tetraose in a single-step, highly regioselective transformation.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB00424F

Reference36 articles.

1. Health promoting aspects of milk oligosaccharides

2. Human milk oligosaccharides: Every baby needs a sugar mama

3. Biotechnological production of human milk oligosaccharides

4. Human Milk Oligosaccharides (HMOS)

5. Glycosynthases: Mutant Glycosidases for Oligosaccharide Synthesis

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