DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules
Author:
Affiliation:
1. Department of Organic Chemistry
2. NCCR Chemical Biology
3. University of Geneva
4. Switzerland
5. Institut de Science et Ingénierie Supramoléculaires (ISIS – UMR 7006)
6. Université de Strasbourg – CNRS
7. F67000 Strasbourg
8. France
Abstract
A focused library for Hsp70 was prepared from fragments identified from an array combinatorially pairing two libraries of small molecule fragments. Screening of the focus library yielded high affinity ligand to Hsp70.
Funder
European Research Council
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/SC/C4SC01654H
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1. Navigating chemical space for biology and medicine
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