Tetramate derivatives by chemoselective Dieckmann ring closure of<i>allo</i>-phenylserines, and their antibacterial activity-Reference-Cited by-同舟云学术

Tetramate derivatives by chemoselective Dieckmann ring closure ofallo-phenylserines, and their antibacterial activity

Published:2023 Issue:19 Volume:21 Page:4061-4071
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Saney Liban¹,Christensen Kirsten E.¹,Genov Miroslav²^ORCID,Pretsch Alexander²,Pretsch Dagmar²,Moloney Mark G.¹³^ORCID

Affiliation:

1. The Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK

2. Oxford Antibiotic Group, The Oxford Science Park, Magdalen Centre, Oxford OX4 4GA, UK

3. Oxford Suzhou Centre for Advanced Research, Building A, 388 Ruo Shui Road, Suzhou Industrial Park, Jiangsu, 215123, P.R. China

Abstract

Tetramates derived from phenylserines are obtained chemoselectively and diastereoselectively, and after derivatisation as their amides, in some cases exhibit excellent antibacterial activity against Gram-positive bacteria.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB00376K

Reference31 articles.

1. 3-Acyltetramic Acids: A Decades-Long Approach to a Fascinating Natural Product Family

2. Tetramic and tetronic acids: An update on new derivatives and biological aspects

3. Naturally Occurring Tetramic Acids: Structure, Isolation, and Synthesis

4. Functionalised bicyclic tetramates derived from cysteine as antibacterial agents

5. Regioselective Dieckmann cyclisations leading to enantiopure highly functionalised tetramic acid derivatives

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