Synthesis of fused tetramate-oxazolidine and -imidazolidine derivatives and their antibacterial activity-Reference-Cited by-同舟云学术

Synthesis of fused tetramate-oxazolidine and -imidazolidine derivatives and their antibacterial activity

Published:2023 Issue:23 Volume:21 Page:4801-4809
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Saney Liban¹,Panduwawala Tharindi¹,Li Xiang¹²,Christensen Kirsten E.¹,Genov Miroslav³^ORCID,Pretsch Alexander³,Pretsch Dagmar³,Moloney Mark G.¹⁴^ORCID

Affiliation:

1. The Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK

2. Department of Pharmaceutical Engineering, China Pharmaceutical University, Nanjing, 211198, P. R. China

3. Oxford Antibiotic Group, The Oxford Science Park, Magdalen Centre, Oxford OX4 4GA, UK

4. Oxford Suzhou Centre for Advanced Research, Suzhou Industrial Park, Building A, 388 Ruo Shui Road, Jiangsu, 215123, P. R. China

Abstract

Chemoselective ring closure of malonamides gives oxazolidine- or imidazolidine fused tetramates, some of which show antibacterial activity against Gram positive organism; these occupy a well-defined region of chemical space.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB00594A

Reference26 articles.

1. Tetramic and tetronic acids: An update on new derivatives and biological aspects

2. Naturally Occurring Tetramic Acids: Structure, Isolation, and Synthesis

3. Diazo Tetramic Acids Provide Access to Natural-Like Spirocyclic Δ^α,β-Butenolides through Rh(II)-Catalyzed O–H Insertion/Base-Promoted Cyclization

4. Tetramate Derivatives by Chemoselective Dieckmann Ring Closure of threo-Phenylserines and Their Antibacterial Activity

5. Tetramate derivatives by chemoselective Dieckmann ring closure ofallo-phenylserines, and their antibacterial activity

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