Synthetic strategies towards mycolactone A/B, an exotoxin secreted by Mycobacterium ulcerans-Reference-Cited by-同舟云学术

Synthetic strategies towards mycolactone A/B, an exotoxin secreted by Mycobacterium ulcerans

Published:2017 Issue:12 Volume:4 Page:2380-2386
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Saint-Auret Sarah¹²³⁴⁵,Abdelkafi Hajer¹²³⁴⁵,Le Nouen Didier⁶⁷⁸⁵,Bisseret Philippe¹²³⁴⁵,Blanchard Nicolas¹²³⁴⁵^ORCID

Affiliation:

1. Université de Strasbourg

2. CNRS

3. Laboratoire de Chimie Moléculaire UMR 7509

4. 67000 Strasbourg

5. France

6. Université de Haute-Alsace

7. Laboratoire de Chimie Organique et Bioorganique EA 4566

8. 68093 Mulhouse Cedex

Abstract

Pitfalls and dead-ends pave the way to mycolactone A/B. This full account reports synthetic efforts towards this natural product that eventually culminated in a de novo total synthesis.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/QO/C7QO00608J

Reference80 articles.

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2. Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans

3. Buruli Ulcer (Mycobacterium ulcerans Infection): a Re-emerging Disease

4. Chemistry of mycolactones, the causative toxins of Buruli ulcer

5. History, biology and chemistry of Mycobacterium ulcerans infections (Buruli ulcer disease)

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