Design, synthesis and biological evaluation of novel 1,2,4-triazolo and 1,2,4-triazino[4,3-a]quinoxalines as potential anticancer and antimicrobial agents-Reference-Cited by-同舟云学术

Design, synthesis and biological evaluation of novel 1,2,4-triazolo and 1,2,4-triazino[4,3-a]quinoxalines as potential anticancer and antimicrobial agents

Published:2015 Issue:1 Volume:6 Page:202-211
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Issa Doaa A. E.¹²³⁴⁵,Habib Nargues S.¹²³⁴⁵,Abdel Wahab Abeer E.⁶⁷⁴⁵

Affiliation:

1. Department of Pharmaceutical Chemistry

2. Faculty of Pharmacy

3. University of Alexandria

4. Alexandria

5. Egypt

6. Genetic Engineering and Biotechnology Research Institute (GEBRI)

7. City for Scientific Research and Technology Application

Abstract

Compound 9a showed dual anticancer and antimicrobial activity and compound 16 showed a broad spectrum antimicrobial activity.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C4MD00257A

Reference27 articles.

1. Synthesis, anticancer activity and pharmacokinetic analysis of 1-[(substituted 2-alkoxyquinoxalin-3-yl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives

2. Drug—DNA interactions

3. DNA Sequence Specificity for Topoisomerase II Poisoning by the Quinoxaline Anticancer Drugs XK469 and CQS

4. Induction of apoptosis by the new anticancer drug XK469 in human ovarian cancer cell lines

5. Synthesis and anticancer activity evaluation of new 2-alkylcarbonyl and 2-benzoyl-3-trifluoromethyl-quinoxaline 1,4-di-N-oxide derivatives

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