Synthesis ofN-acetylglucosamine andN-acetylallosamine resorcinarene-based multivalent β-thio-glycoclusters: unexpected affinity ofN-acetylallosamine ligands towards Wheat Germ Agglutinin-Reference-Cited by-同舟云学术

Synthesis ofN-acetylglucosamine andN-acetylallosamine resorcinarene-based multivalent β-thio-glycoclusters: unexpected affinity ofN-acetylallosamine ligands towards Wheat Germ Agglutinin

Published:2020 Issue:35 Volume:18 Page:6853-6865
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Cristófalo Alejandro E.¹²³⁴⁵^ORCID,Cagnoni Alejandro J.⁶⁷⁸⁴⁵^ORCID,Uhrig María Laura¹²³⁴⁵^ORCID

Affiliation:

1. Universidad de Buenos Aires

2. Facultad de Ciencias Exactas y Naturales

3. Departamento de Química Orgánica

4. Buenos Aires

5. Argentina

6. Laboratorio de Glicómica Funcional y Molecular

7. Instituto de Biología y Medicina Experimental

8. IBYME-CONICET

Abstract

Resorcinarene-based glycoclusters bearing β-S-GlcNAc and β-S-AllNAc residues were synthesized and ITC and molecular docking calculations provided evidence of their strong affinity towards WGA.

Funder

Universidad de Buenos Aires

Consejo Nacional de Investigaciones Científicas y Técnicas

Agencia Nacional de Promoción Científica y Tecnológica

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB01498B

Reference74 articles.

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3. Amphiphilic calixresorcinarene associates as effective solubilizing agents for hydrophobic organic acids: construction of nano-aggregates

4. Macrocyclic Glycoclusters: From Amphiphiles through Nanoparticles to Glycoviruses

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