Synthesis, self-assembly and Langerin recognition studies of a resorcinarene-based glycocluster exposing a hyaluronic acid thiodisaccharide mimetic-Reference-Cited by-同舟云学术

Synthesis, self-assembly and Langerin recognition studies of a resorcinarene-based glycocluster exposing a hyaluronic acid thiodisaccharide mimetic

Published:2021 Issue:29 Volume:19 Page:6455-6467
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Cristófalo Alejandro E.¹²³⁴⁵^ORCID,Nieto Pedro M.⁶⁷⁸⁹¹⁰^ORCID,Thépaut Michel¹¹¹²¹³¹⁴¹⁵,Fieschi Franck¹¹¹²¹³¹⁴¹⁵,Di Chenna Pablo H.¹²³⁴⁵^ORCID,Uhrig María Laura¹²³⁴⁵^ORCID

Affiliation:

1. Departamento de Química Orgánica

2. Facultad de Ciencias Exactas y Naturales

3. Universidad de Buenos Aires

4. Ciudad Universitaria

5. C1428EGA Buenos Aires

6. Glycosystems Laboratory

7. Instituto de Investigaciones Químicas (IIQ)

8. cicCartuja

9. CSIC and Universidad de Sevilla

10. 41092 Sevilla

11. Univ. Grenoble Alpes

12. CNRS

13. CEA

14. Institut de Biologie Structurale

15. F-38044 Grenoble

Abstract

A synthetic glycoresorcinarene exposing a thiodisaccharide self-assembles to form spherical micelles in water. Its interaction with Langerin was studied leading to the formation of complex aggregates consistent with a 1 : 1 stoichiometry.

Funder

Universidad de Buenos Aires

Consejo Nacional de Investigaciones Científicas y Técnicas

Agencia Nacional de Promoción Científica y Tecnológica

Ministerio de Ciencia, Innovación y Universidades

Agencia Estatal de Investigación

European Regional Development Fund

Asociación Universitaria Iberoamericana de Postgrado

French Infrastructure for Integrated Structural Biology

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)