Screening and optimization of phage display cyclic peptides against the WDR5 WBM site-Reference-Cited by-同舟云学术

Screening and optimization of phage display cyclic peptides against the WDR5 WBM site

Published:2023 Issue:10 Volume:14 Page:2048-2057
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Song Lingyu¹²,Cao Jiawen¹²,Chen Lin²,Du Zhiyan²,Zhang Naixia¹³,Cao Danyan²,Xiong Bing¹²⁴^ORCID

Affiliation:

1. Department of College of Pharmacy, University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049, China

2. Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China

3. Department of Analytical Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China

4. State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China

Abstract

We reported two improved screenings based on the phage display technique to discover novel peptidic inhibitors against the WDR5 WBM site, and the optimized cyclic peptide CYC3 was acquired, which could be subjected to further biological evaluation.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00288H

Reference41 articles.

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4. Structure-Based Discovery of a Series of NSD2-PWWP1 Inhibitors

5. Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells

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