Synthesis of <i>gem</i>-difluorinated pentacyclic indenopyrazolopyrazolones <i>via</i> Rh(<scp>iii</scp>)-catalyzed cascade C–H functionalization/[3 + 2] dipolar cycloaddition-Reference-Cited by-同舟云学术

Synthesis of gem-difluorinated pentacyclic indenopyrazolopyrazolones via Rh(iii)-catalyzed cascade C–H functionalization/[3 + 2] dipolar cycloaddition

Published:2024 Issue:9 Volume:11 Page:2512-2517
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Liu Fu-Xiaomin¹²,Chen Weijie²,Cai Ying²,Zhou Zhi²^ORCID,Yi Wei²^ORCID,Cheng Kui¹^ORCID

Affiliation:

1. Guangdong Provincial Key Laboratory of New Drug Screening and Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China

2. Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 511436, China

Abstract

A Rh(iii)-catalysed cascade C–H functionalization/[3 + 2] dipolar cycloaddition was realized to deliver gem-difluorinated pentacyclic indenopyrazolopyrazolones with four continuous chiral carbon centres in a one-pot fashion.

Funder

National Natural Science Foundation of China

Guangzhou Medical University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D4QO00009A

Reference49 articles.

1. An overview on the synthetic and medicinal perspectives of indenopyrazoles

2. Synthesis and biological evaluation of pyrazolo[1,5-a]pyrimidine-3-carboxamide as antimicrobial agents

3. Transition-Metal-Catalyzed C–H Bond Activation for the Formation of C–C Bonds in Complex Molecules

4. Nickel-Catalyzed Functionalization Reactions Involving C–H Bond Activation via an Amidate-Promoted Strategy and Its Extension to the Activation of C–F, C–O, C–S, and C–CN Bonds

5. The crucial role of silver(i)-salts as additives in C–H activation reactions: overall analysis of their versatility and applicability

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