A convenient and versatile SNAr-decarboxylation protocol for the construction of C(sp2)–C(sp3) bonds-Reference-Cited by-同舟云学术

A convenient and versatile S_NAr-decarboxylation protocol for the construction of C(sp²)–C(sp³) bonds

Published:2022 Issue:53 Volume:58 Page:7435-7438
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Burtea Alexander¹,DeForest Jacob¹^ORCID,Baldwin Neil²,Leverett Carolyn²,Gallego Gary M.¹^ORCID

Affiliation:

1. Oncology Medicinal Chemistry, Pfizer Worldwide Research, Development and Medical, 10770 Science Center Drive, San Diego, CA 92121, USA

2. Pfizer Medicine Design, 445 Eastern Point Rd, Groton, CT 06340, USA

Abstract

A versatile and operationally simple one-pot procedure for the construction of C(sp2)-C(sp3) bonds via a nucleophilic aromatic substitution-decarboxylation sequence is described.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC01551J

Reference40 articles.

1. Improvement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and Symmetry

2. Impact of Physicochemical Properties on Dose and Hepatotoxicity of Oral Drugs

3. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

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