Synthesis and determination of absolute configuration of a non-peptidic αvβ6 integrin antagonist for the treatment of idiopathic pulmonary fibrosis
Author:
Affiliation:
1. Medicinal Chemistry
2. Fibrosis and Lung Injury DPU
3. Respiratory Therapeutic Area
4. GlaxoSmithKline Medicines Research Centre
5. Stevenage
6. Spectroscopy
7. Platform Technology & Science
8. UK
Abstract
Integrin inhibitor (cell adhesion assays) pIC50 αvβ6 = 8.4, αvβ3 = 6.0, αvβ5 = 5.9 and αvβ8 = 7.7.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00496B
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4. Inhibition of Integrin αvβ6, an Activator of Latent Transforming Growth Factor-β, Prevents Radiation-induced Lung Fibrosis
5. Rhodium-Catalyzed Asymmetric 1,4-Addition of Aryl- and Alkenylboronic Acids to Enones
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