Design, Synthesis, and Evaluation of Indolinones as Triple Angiokinase Inhibitors and the Discovery of a Highly Specific 6-Methoxycarbonyl-Substituted Indolinone (BIBF 1120)
Author:
Affiliation:
1. Department of Chemical Research
2. Department of Non-Clinical Drug Safety
3. Department of Lead Discovery
4. Department of Drug Discovery Support
5. Boehringer Ingelheim RCV GmbH & Co. KG, A-1121 Vienna, Austria
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm900431g
Reference34 articles.
1. Transplacental Carcinogenesis by Stilbestrol
2. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
3. Bevacizumab in the management of solid tumors
4. Design and Discovery of Small Molecules Targeting Raf-1 Kinase
5. Discovery and development of sorafenib: a multikinase inhibitor for treating cancer
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