Discovery and Development of Highly Potent and Orally Bioavailable Nonpeptidic α<sub>v</sub>β<sub>6</sub> Integrin Inhibitors-Reference-Cited by-同舟云学术

Discovery and Development of Highly Potent and Orally Bioavailable Nonpeptidic α_vβ₆ Integrin Inhibitors

Published:2024-09-13 Issue: Volume: Page:
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Procopiou Panayiotis A.¹^ORCID,Barrett John²,Crawford Matthew H. J.¹,Hatley Richard J. D.¹^ORCID,Hancock Ashley P.¹,Pritchard John M.¹,Rowedder James E.³,Copley Royston C. B.⁴,Slack Robert J.³,Sollis Steven L.¹,Thorp Lee R.¹,Lippa Rhys A.¹,Macdonald Simon J. F.¹^ORCID,Barrett Tim N.¹^ORCID

Affiliation:

1. Medicinal Science & Technology, Medicine Design, Stevenage SG1 2NY, United Kingdom

2. Discovery Drug Metabolism & Pharmacokinetics, In Vitro In Vivo Translation, Stevenage SG1 2NY, United Kingdom

3. Translational Biology, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, United Kingdom

4. Medicine Development & Supply, Drug Substance Development, Materials Science, Stevenage SG1 2NY, United Kingdom

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01430

Reference30 articles.

1. αvβ6 Integrin Regulates Renal Fibrosis and Inflammation in Alport Mouse

2. The Coagulation System Contributes to αVβ6 Integrin Expression and Liver Fibrosis Induced by Cholestasis

3. Inhibition of Integrin αvβ6, an Activator of Latent Transforming Growth Factor-β, Prevents Radiation-induced Lung Fibrosis

4. A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

5. Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation