Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones-Reference-Cited by-同舟云学术

Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones

Published:2015 Issue:9 Volume:13 Page:2716-2725
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Mollet Karen¹²³⁴⁵,Decuyper Lena¹²³⁴⁵,Vander Meeren Saskia¹²³⁴⁵,Piens Nicola¹²³⁴⁵,De Winter Karel⁶³⁴⁵⁷,Desmet Tom⁶³⁴⁵⁷,D'hooghe Matthias¹²³⁴⁵

Affiliation:

1. SynBioC Research Group

2. Department of Sustainable Organic Chemistry and Technology

3. Faculty of Bioscience Engineering

4. Ghent University

5. B-9000 Ghent

6. Department of Biochemical and Microbial Technology

7. Belgium

Abstract

Trans- andcis-2-aryl-3-(2-cyanoethyl)aziridines were transformed into 4-[aryl(alkylamino)methyl]butyrolactones and/or 5-[aryl(hydroxy)methyl]pyrrolidin-2-onesviachemical and enzymatic hydrolysis of the cyano group, followed by ring expansion.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB02615B

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