Exploring the intramolecular catalysis of the proton exchange process to modulate the relaxivity of Gd(iii)-complexes of HP-DO3A-like ligands-Reference-Cited by-同舟云学术

Exploring the intramolecular catalysis of the proton exchange process to modulate the relaxivity of Gd(iii)-complexes of HP-DO3A-like ligands

Published:2018 Issue:72 Volume:54 Page:10056-10059
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Carnovale Irene Maria¹²³^ORCID,Lolli Marco Lucio¹²³^ORCID,Serra Sonia Colombo⁴⁵³^ORCID,Mingo Alberto Fringuello⁴⁵³^ORCID,Napolitano Roberta⁴⁵³,Boi Valeria⁴⁵³,Guidolin Nicol⁴⁵³,Lattuada Luciano⁴⁵³,Tedoldi Fabio⁴⁵³,Baranyai Zsolt⁴⁵³^ORCID,Aime Silvio⁶⁷⁸³^ORCID

Affiliation:

1. Department of Drug Science and Technology, University of Torino

2. 10125 Torino

3. Italy

4. Bracco Imaging Spa, Bracco Research Centre

5. 10010 Colleretto Giacosa (TO)

6. Department of Molecular Biotechnologies and Health Sciences

7. Molecular Imaging Center, University of Torino

8. 10126 Torino

Abstract

The Gd^III complex of Ph-HP-DO3A shows the highest contribution to the relaxivity by the intramolecular proton exchange of the –OH group.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC05284K

Reference20 articles.

1. É. Tóth , L.Helm and A.Merbach , in The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging , John Wiley & Sons, Ltd , 2013 , pp. 25–81

2. Prototropic and Water-Exchange Processes in Aqueous Solutions of Gd(III) Chelates

3. Macrocyclic paramagnetic agents for MRI: Determinants of relaxivity and strategies for their improvement

4. Exploiting the Proton Exchange as an Additional Route to Enhance the Relaxivity of Paramagnetic MRI Contrast Agents

5. Combined High Resolution NMR and 1H and 17O Relaxometric Study Sheds Light on the Solution Structure and Dynamics of the Lanthanide(III) Complexes of HPDO3A

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