Macrocyclic paramagnetic agents for MRI: Determinants of relaxivity and strategies for their improvement

Author:

Fringuello Mingo Alberto12,Colombo Serra Sonia1,Baroni Simona3,Cabella Claudia1,Napolitano Roberta1,Hawala Ivan3,Carnovale Irene Maria4,Lattuada Luciano1,Tedoldi Fabio1,Aime Silvio5

Affiliation:

1. Bracco Imaging Spa, Bracco Research Center, Via Ribes 5; 10010 Colleretto Giacosa (TO) Italy

2. Dipartimento di Fisica; Università degli Studi di Torino, Via Pietro Giuria 1; 10125 Torino (TO) Italy

3. Dipartimento di Biotecnologie Molecolari e Scienze per la salute - Centro di Molecular Imaging; Università degli Studi di Torino, Via Nizza 52; 10126 Torino (TO) Italy

4. Dipartimento di Scienza e Tecnologia del Farmaco; Università degli Studi di Torino, Via Pietro Giuria 9; 10125 Torino (TO) Italy

5. Dipartimento di Chimica I.F.M; Università degli Studi di Torino, Via Pietro Giuria 7; 10125 Torino (TO) Italy

Publisher

Wiley

Subject

Radiology, Nuclear Medicine and imaging

Reference37 articles.

1. Considerations in the selection of a new gadolinium-based contrast agent;Tweedle;Appl Radiol,2014

2. Are there differences between macrocyclic gadolinium contrast agents for brain tumor imaging? Results of a multicenter intraindividual crossover comparison of gadobutrol with gadoteridol (the TRUTH study);Maravilla;Am J Neuroradiol,2015

3. Gadolinium contrast agents for CNS imaging: current concepts and clinical evidence;Kanal;Am J Neuroradiol,2014

4. Physicochemical properties of gadoteridol and other magnetic resonance contrast agents;Tweedle;Ivest Radiol,1992

5. Field strength dependence of R1 and R2* relaxivities of human whole blood to ProHance, Vasovist, and deoxyhemoglobin;Blockley;Magn Reson Med,2008

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