A facile one-pot multi-component synthesis of novel adamantine substituted imidazo[1,2-a]pyridine derivatives: identification and structure–activity relationship study of their anti-HIV-1 activity-Reference-Cited by-同舟云学术

A facile one-pot multi-component synthesis of novel adamantine substituted imidazo[1,2-a]pyridine derivatives: identification and structure–activity relationship study of their anti-HIV-1 activity

Published:2016 Issue:97 Volume:6 Page:95177-95188
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Tazeem Tazeem¹²³⁴⁵,Han Xin¹²³⁴⁵,Zhou Qingjun⁶⁷⁸⁹⁵,Wei Jingchen¹⁰¹¹¹²⁵,Tien Po¹²³⁴⁵,Yang Guichun⁶⁷⁸⁹⁵,Wu Shuwen¹²³⁴⁵,Dong Chune¹³¹⁴¹⁵⁵

Affiliation:

1. State Key Laboratory of Virology

2. College of Life Sciences

3. Wuhan University

4. Wuhan 430072

5. China

6. Hubei Collaborative Innovation Center for Advanced Organochemical Materials

7. Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules

8. Hubei University

9. Wuhan 430062

10. Department of Pharmacology

11. Guilin Medical University

12. Guilin

13. Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals

14. Wuhan University School of Pharmaceutical Sciences

15. Wuhan 430071

Abstract

A series of adamantine substituted imidazo[1,2-a]pyridine derivatives were developed through a one-pot multi-component Groebke–Blackburn–Bienaymé reaction, among them several compounds were identified to be the potent inhibitors against HIV-1 cells.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA17656A

Reference78 articles.

1. AIDS therapy: First tentative signs of therapeutic promise

2. Current status and challenges of antiretroviral research and therapy

3. Process Improvements for the Manufacture of Tenofovir Disoproxil Fumarate at Commercial Scale

4. Efficient Discovery of Potent Anti-HIV Agents Targeting the Tyr181Cys Variant of HIV Reverse Transcriptase

5. In search of a treatment for HIV – current therapies and the role of non-nucleoside reverse transcriptase inhibitors (NNRTIs)

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. HPW-Catalyzed environmentally benign approach to imidazo[1,2-a]pyridines;Beilstein Journal of Organic Chemistry;2024-03-19

2. Synthesis of Hantzsch poly-substituted pyridines containing adamantyl moiety;Monatshefte für Chemie - Chemical Monthly;2024-02

3. Design, synthesis and biological evaluation of indole-2-carboxylic acid derivatives as novel HIV-1 integrase strand transfer inhibitors;RSC Advances;2024

4. Gas‐phase fragmentation of protonated 3‐phenoxy imidazo[1,2‐a] pyridines using tandem mass spectrometry and computational chemistry;Journal of Mass Spectrometry;2021-12

5. Synthesis, biological evaluation, and molecular docking studies of novel pyrazole, pyrazoline‐clubbed pyridine as potential antimicrobial agents;Journal of Heterocyclic Chemistry;2021-01-05