The convenient Michael addition of imidazoles to acrylates catalyzed by Lipozyme TL IM from Thermomyces lanuginosus in a continuous flow microreactor-Reference-Cited by-同舟云学术

The convenient Michael addition of imidazoles to acrylates catalyzed by Lipozyme TL IM from Thermomyces lanuginosus in a continuous flow microreactor

Published:2019 Issue:4 Volume:17 Page:807-812
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Du Li-Hua¹²³⁴^ORCID,Dong Zhen¹²³⁴,Long Rui-Jie¹²³⁴,Chen Ping-Feng¹²³⁴,Xue Miao¹²³⁴,Luo Xi-Ping⁵⁶³⁷

Affiliation:

1. College of Pharmaceutical Science

2. ZheJiang University of Technology

3. Hangzhou

4. People's Republic of China

5. Zhejiang Provincial Key Laboratory of Chemical Utilization of Forestry Biomass

6. Zhejiang A&F University

7. China

Abstract

A fast and green Michael addition based protocol in a continuous flow microreactor was developed, an innovation which may open up the use of enzymatic microreactors in imidazole analogue biotransformations.

Funder

Natural Science Foundation of Zhejiang Province

National Natural Science Foundation of China

Zhejiang University of Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C8OB02533A

Reference58 articles.

1. Bacterial Symbionts: Prospects for the Sustainable Production of Invertebrate-Derived Pharmaceuticals

2. Comprehensive Review in Current Developments of Imidazole-Based Medicinal Chemistry

3. Next-Generation Hypoxic Cell Radiosensitizers: Nitroimidazole Alkylsulfonamides

4. Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases

5. Structure-Based Drug Design of Novel Aurora Kinase A Inhibitors: Structural Basis for Potency and Specificity

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