Structure-Based Drug Design of Novel Aurora Kinase A Inhibitors: Structural Basis for Potency and Specificity-Reference-Cited by-同舟云学术

Structure-Based Drug Design of Novel Aurora Kinase A Inhibitors: Structural Basis for Potency and Specificity

Published:2009-01-13 Issue:4 Volume:52 Page:1050-1062
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Coumar Mohane Selvaraj¹,Leou Jiun-Shyang¹,Shukla Paritosh¹,Wu Jian-Sung¹,Dixit Ajay Kumar¹,Lin Wen-Hsing¹,Chang Chun-Yu¹,Lien Tzu-Wen¹,Tan Uan-Kang¹,Chen Chun-Hwa¹,Hsu John T.-A.¹,Chao Yu-Sheng¹,Wu Su-Ying¹,Hsieh Hsing-Pang¹

Affiliation:

1. Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan, ROC, and Department of Chemical and Materials Engineering, Technology and Science Institute of Northern Taiwan, Taipei 112, Taiwan, ROC

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801270e

Reference25 articles.

1. Roles of Aurora Kinases in Mitosis and Tumorigenesis

2. The cellular geography of Aurora kinases

3. Structural basis for potent inhibition of the Aurora kinases and a T315I multi-drug resistant mutant form of Abl kinase by VX-680

4. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

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