Enantioselective synthesis of spiro-N,O-ketals via iridium and Brønsted acid co-catalyzed asymmetric formal [4+2] cycloaddition-Reference-Cited by-同舟云学术

Enantioselective synthesis of spiro-N,O-ketals via iridium and Brønsted acid co-catalyzed asymmetric formal [4+2] cycloaddition

Published:2024 Issue:11 Volume:60 Page:1448-1451
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Xie Xiang-Qi¹,Li Xingguang¹^ORCID,Liu Pei-Nian¹^ORCID

Affiliation:

1. Shanghai Key Laboratory of Functional Materials Chemistry, Key Laboratory for Advanced Materials, School of Chemistry and Molecular Engineering, East China University of Science & Technology, Shanghai 200237, China

Abstract

An asymmetric formal [4+2] cycloaddition of cyclic enamides with 2-(1-hydroxyallyl)phenol via iridium and Brønsted acid co-catalysis has been achieved to afford chiral N-unsubstituted spiro-N,O-ketals.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D3CC05923E

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