Regioselective <i>O</i>-alkylation of 2-pyridones by TfOH-catalyzed carbenoid insertion-Reference-Cited by-同舟云学术

Regioselective O-alkylation of 2-pyridones by TfOH-catalyzed carbenoid insertion

Published:2023 Issue:1 Volume:59 Page:106-109
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Yan Zhewei¹²,He Hangli¹²,Yuan Dabiao¹²,Yan Qiongjiao¹,Wang Wei¹^ORCID,Jiang Haipeng¹,Wang Haifeng¹²,Chen Fener¹³⁴^ORCID

Affiliation:

1. Pharmaceutical Research Institute, Wuhan Institute of Technology, Wuhan, 430205, China

2. School of Chemical Engineering & Pharmacy, Wuhan Institute of Technology, Wuhan, 430205, China

3. Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai, 200433, China

4. Shanghai Engineering Center of Industrial Catalysis for Chiral Drugs, Shanghai, 200433, China

Abstract

We have developed a novel TfOH-catalyzed regioselective O-alkylation of 2-pyridones with diazo compounds in high regioselectivity. This protocol is characterized by mild reaction conditions, metal-free, and simplicity.

Funder

Hubei Provincial Department of Education

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CC/D2CC05676C

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