Structure-based Design of Pyridone–Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition-Reference-Cited by-同舟云学术

Structure-based Design of Pyridone–Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition

Published:2018-03-10 Issue:8 Volume:61 Page:3516-3540
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Reich Siegfried H.¹^ORCID,Sprengeler Paul A.¹,Chiang Gary G.¹^ORCID,Appleman James R.²,Chen Joan¹,Clarine Jeff¹,Eam Boreth¹,Ernst Justin T.¹,Han Qing³,Goel Vikas K.¹,Han Edward Z. R.³,Huang Vera⁴,Hung Ivy N. J.¹,Jemison Adrianna⁵,Jessen Katti A.⁶,Molter Jolene¹,Murphy Douglas⁷,Neal Melissa¹,Parker Gregory S.¹,Shaghafi Michael⁸,Sperry Samuel¹,Staunton Jocelyn¹,Stumpf Craig R.¹,Thompson Peggy A.¹,Tran Chinh¹,Webber Stephen E.⁹,Wegerski Christopher J.¹,Zheng Hong³,Webster Kevin R.¹

Affiliation:

1. eFFECTOR Therapeutics, 11180 Roselle Street, San Diego, California 92121, United States

2. Primmune Therapeutics, Inc., 3210 Merryfield Row, San Diego, California 92121, United States

3. Structure-Based Design, Inc., 6048 Cornerstone Court West #D, San Diego, California 92121, United States

4. Molecular Stethoscope, 10835 Road to the Cure #100, San Diego, California 92121, United States

5. Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States

6. Oncternal Therapeutics, 3525 Del Mar Heights Road #821, San Diego, California 92130, United States

7. Molcentrics, Inc., 11835 Carmel Mountain Road #1304-110, San Diego, California 92128, United States

8. Abide Therapeutics, 10835 Road to the Cure, Suite 250, San Diego, California 92121, United States

9. Polaris Pharmaceuticals, 9373 Towne Centre Drive #150, San Diego, California 92121, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01795

Reference69 articles.

1. Translation from unconventional 5′ start sites drives tumour initiation

2. Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development

3. Targeting the translation machinery in cancer

4. Mitogen-activated Protein Kinase (MAPK) Interacting Kinases 1 and 2 (MNK1 and MNK2) as Targets for Cancer Therapy: Recent Progress in the Development of MNK Inhibitors

5. New frontiers in translational control of the cancer genome

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