New frontiers in translational control of the cancer genome

Author:

Truitt Morgan L.,Ruggero Davide

Publisher

Springer Science and Business Media LLC

Subject

General Earth and Planetary Sciences,General Environmental Science

Reference254 articles.

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3. Furic, L. et al. eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. Proc. Natl Acad. Sci. USA 107, 14134–14139 (2010). This paper describes the generation of a knock-in mouse that expresses a non-phosphorylatable form of eIF4E and demonstrates a crucial role for eIF4E phosphorylation during in vivo tumorigenesis.

4. Hsieh, A. C. et al. Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP–eIF4E. Cancer Cell 17, 249–261 (2010).

5. Faller, W. J. et al. mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. Nature 517, 497–500 (2015). This exciting study demonstrates that oncogenic activation of translation elongation through eEF2 can be rate limiting for tumorigenesis.

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