New frontiers in translational control of the cancer genome
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Earth and Planetary Sciences,General Environmental Science
Link
http://www.nature.com/articles/nrc.2016.27.pdf
Reference254 articles.
1. Miluzio, A. et al. Impairment of cytoplasmic eIF6 activity restricts lymphomagenesis and tumor progression without affecting normal growth. Cancer Cell 19, 765–775 (2011). This study demonstrated that mice happloinsufficient for eIF6, which regulates the formation of functional 80S ribosomes, show delayed in vivo tumorigenesis and reduced tumour growth, thus uncovering a rate-limiting role for translation initiation independent of the eIF4F complex.
2. Barna, M. et al. Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency. Nature 456, 971–975 (2008). This is the first study to genetically demonstrate that the ability of MYC to drive increased protein synthesis is a key determinant of oncogenicity.
3. Furic, L. et al. eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. Proc. Natl Acad. Sci. USA 107, 14134–14139 (2010). This paper describes the generation of a knock-in mouse that expresses a non-phosphorylatable form of eIF4E and demonstrates a crucial role for eIF4E phosphorylation during in vivo tumorigenesis.
4. Hsieh, A. C. et al. Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP–eIF4E. Cancer Cell 17, 249–261 (2010).
5. Faller, W. J. et al. mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. Nature 517, 497–500 (2015). This exciting study demonstrates that oncogenic activation of translation elongation through eEF2 can be rate limiting for tumorigenesis.
Cited by 261 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Stratification of Colorectal Patients Based on Survival Analysis Shows the Value of Consensus Molecular Subtypes and Reveals the CBLL1 Gene as a Biomarker of CMS2 Tumours;International Journal of Molecular Sciences;2024-02-05
2. RNA G-quadruplex dynamic steers the crosstalk between protein synthesis and energy metabolism;2024-01-31
3. A second-generation eIF4A RNA helicase inhibitor exploits translational reprogramming as a vulnerability in triple-negative breast cancer;Proceedings of the National Academy of Sciences;2024-01-17
4. Establishment of novel ferroptosis-related prognostic subtypes correlating with immune dysfunction in prostate cancer patients;Heliyon;2024-01
5. The Role of tRNA-Centered Translational Regulatory Mechanisms in Cancer;Cancers;2023-12-22
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3