Synthesis of Zn(<scp>ii</scp>) coordination complexes, their molecular design and docking with SARS-CoV-2 RBD protein and Omicron spike protein-Reference-Cited by-同舟云学术

Synthesis of Zn(ii) coordination complexes, their molecular design and docking with SARS-CoV-2 RBD protein and Omicron spike protein

Published:2024 Issue:20 Volume:48 Page:9287-9313
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Singh Simranjeet¹,Choudhary Mukesh¹^ORCID

Affiliation:

1. Department of Chemistry, National Institute of Technology Patna, Patna-800005, Bihar, India

Abstract

Two Zn(ii) complexes [Zn(L)(en)]ClO4 (1) and [Zn(L)2] (2) were synthesized and designed and their molecular docking with the SARS-CoV-2 RBD protein and Omicron spike protein were studied for assessing them as possible therapeutic drug candidates against SARS-CoV-2 and its Omicron variant.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NJ/D3NJ04714H

Reference114 articles.

1. Distinct core glycan and O-glycoform utilization of SARS-CoV-2 Omicron variant Spike protein RBD revealed by top-down mass spectrometry

2. Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in South Africa: a data linkage study

3. Omicron Binding Mode: Contact Analysis and Dynamics of the Omicron Receptor-Binding Domain in Complex with ACE2

4. Structural modeling of Omicron spike protein and its complex with human ACE-2 receptor: Molecular basis for high transmissibility of the virus

5. Molecular basis of receptor binding and antibody neutralization of Omicron

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