Distinct core glycan and <i>O</i>-glycoform utilization of SARS-CoV-2 Omicron variant Spike protein RBD revealed by top-down mass spectrometry-Reference-Cited by-同舟云学术

Distinct core glycan and O-glycoform utilization of SARS-CoV-2 Omicron variant Spike protein RBD revealed by top-down mass spectrometry

Published:2022 Issue:36 Volume:13 Page:10944-10949
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Roberts David S.¹^ORCID,Mann Morgan²^ORCID,Li Brad H.³^ORCID,Kim Donguk³^ORCID,Braiser Allan R.²⁴,Jin Song¹^ORCID,Ge Ying¹³^ORCID

Affiliation:

1. Department of Chemistry, University of Wisconsin–Madison, WI 53706, USA

2. Department of Medicine, School of Medicine and Public Health University of Wisconsin–Madison, WI 53705, USA

3. Department of Cell and Regenerative Biology, University of Wisconsin–Madison, WI 53705, USA

4. Institute for Clinical and Translational Research, University of Wisconsin–Madison, WI 53705, USA

Abstract

Top-down mass spectrometry reveals O-glycoform structural changes in the SARS-CoV-2 Omicron variant. Resolving the mutations and post-translational alterations can inform strategies for designing variant-directed diagnostics and therapeutics.

Funder

National Institute of General Medical Sciences

National Heart, Lung, and Blood Institute

NIH Office of the Director

American Heart Association

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC02132C

Reference32 articles.

1. An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies

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