Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitor-Reference-Cited by-同舟云学术

Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitor

Published:2018 Issue:90 Volume:54 Page:12758-12761
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Swamy Mahadeva M. M.¹²³⁴^ORCID,Murai Yuta¹²³⁴⁵^ORCID,Ohno Yusuke⁶²⁷⁴^ORCID,Jojima Keisuke⁶²⁷⁴,Kihara Akio⁶²⁷⁴,Mitsutake Susumu⁵⁸²³⁴,Igarashi Yasuyuki⁵⁸²³⁴,Yu Jian⁸²⁹⁴,Yao Min⁸²⁹⁴,Suga Yoshiko⁵⁸²³⁴,Anetai Masaki⁵⁸²³⁴,Monde Kenji¹²³⁴⁵^ORCID

Affiliation:

1. Graduate School of Life Science

2. Hokkaido University

3. Sapporo 001-0021

4. Japan

5. Frontier Research Centre for Advanced Material and Life Science

6. Faculty of Pharmaceutical Sciences

7. Sapporo 060-0812

8. Faculty of Advanced Life Science

9. Sapporo 060-0810

Abstract

A monophosphate derivative of ginkgolic acid binds to sphingosine 1-phosphate (S1P) receptors to perform similar functions to the lipid mediator S1P.

Funder

Ministry of Education, Culture, Sports, Science and Technology

Japan Society for the Promotion of Science

Hokkaido University

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC05595E

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